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KMID : 1007420070050010019
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Mood and Emotion
2007 Volume.5 No. 1 p.19 ~ p.24
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Dysfunction of Brain Network in Bipolar Disorder Observed through Neuroimaging Studies
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Seok Jeong-Ho
Kim Jae-Jin
Jon Duk-In
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Abstract
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Glycogen synthase kinase-3 (GSK3) has recently been linked to pathophysiology and therapeutic mechanisms of mood disorders. GSK3 is an important multifunctional enzyme involved in metabolism, gene expression, neuroplasticity, neurogenesis, cell survival and death, and circadian rhythm in central nervous system. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide fine tuning of the multiple actions of GSK3. Many evidences support that GSK3 may be a common target of therapeutic agents for mood disorders. Dysregulated GSK3 in mood disorder could lead to neural dysfunctions and could contribute to the development or pathophysiology of mood disorders. To prove this hypothesis, clinical trials with new, selective, brain-penetrant inhibitors of GSK3 are ultimately required.
2007;5:7-18
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KEYWORD
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Bipolar disorder, Brain network dysfunction
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